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Multiple Choice
When a poison such as cyanide blocks the electron transport chain, glycolysis and the citric acid cycle also eventually stop working. Which of the following is the best explanation for this?
A
A high level of NADH is present in the cell.
B
The uptake of oxygen stops because electron transport was inhibited.
C
Electrons are no longer available from the electron transport chain to power glycolysis and the citric acid cycle.
D
They run out of ADP.
E
NAD+ and FAD are not available for glycolysis and the citric acid cycle to continue.
Verified step by step guidance
1
Understand the role of the electron transport chain: It is the final stage of cellular respiration where electrons are transferred through a series of complexes to ultimately produce ATP. This process also regenerates NAD+ and FAD, which are essential for glycolysis and the citric acid cycle.
Recognize the importance of NAD+ and FAD: These coenzymes are crucial for the continuation of glycolysis and the citric acid cycle. They act as electron carriers, accepting electrons during these processes and becoming NADH and FADH2.
Identify the impact of cyanide: Cyanide inhibits the electron transport chain by binding to cytochrome c oxidase, preventing the transfer of electrons to oxygen. This blockage halts ATP production and the regeneration of NAD+ and FAD.
Connect the inhibition to glycolysis and the citric acid cycle: Without the regeneration of NAD+ and FAD, glycolysis and the citric acid cycle cannot proceed. These processes rely on the availability of these coenzymes to accept electrons and continue the metabolic pathways.
Conclude why NAD+ and FAD are unavailable: The electron transport chain's inhibition by cyanide leads to a lack of NAD+ and FAD regeneration, causing glycolysis and the citric acid cycle to eventually stop due to the accumulation of NADH and FADH2.