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Multiple Choice
When an action potential arrives at the neuromuscular junction, the most immediate result is __________.
A
the release of acetylcholine from the motor neuron
B
the depolarization of the sarcolemma
C
a rise in intracellular Ca2+ levels in the muscle fiber
D
the formation of actin-myosin cross bridges
Verified step by step guidance
1
Understand the sequence of events at the neuromuscular junction: An action potential travels down the motor neuron to the axon terminal.
Recognize that the arrival of the action potential at the axon terminal causes voltage-gated calcium channels to open, allowing Ca2+ ions to enter the neuron.
Identify that the influx of Ca2+ ions into the neuron triggers synaptic vesicles to release acetylcholine (ACh) into the synaptic cleft.
Note that acetylcholine diffuses across the synaptic cleft and binds to receptors on the sarcolemma (muscle cell membrane), leading to depolarization.
Understand that the depolarization of the sarcolemma eventually leads to a rise in intracellular Ca2+ levels and the formation of actin-myosin cross bridges, but these are subsequent steps following the release of acetylcholine.