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Problem A.1a
Match each statement (a–e) with the best answer from the following list: consultand, 50%, prior probability, 66.7%, obligate carrier, 100%.
The Mendelian risk that a person is a heterozygous carrier of a recessive condition
Problem A.1b
Match each statement (a–e) with the best answer from the following list: consultand, 50%, prior probability, 66.7%, obligate carrier, 100%.
A person who on the basis of family history must be a heterozygous carrier of a recessive mutant allele
Problem A.1c
Match each statement (a–e) with the best answer from the following list: consultand, 50%, prior probability, 66.7%, obligate carrier, 100%.
The probability that the healthy brother of a woman with an autosomal recessive condition is a heterozygous carrier
Problem A.1d
Match each statement (a–e) with the best answer from the following list: consultand, 50%, prior probability, 66.7%, obligate carrier, 100%.
The person receiving genetic counseling
Problem A.1e
Match each statement (a–e) with the best answer from the following list: consultand, 50%, prior probability, 66.7%, obligate carrier, 100%.
The probability that the son of a woman with an autosomal recessive condition is a heterozygous carrier
Problem A.3
A couple comes into your genetic counseling practice with a question about the chance a future child of theirs might have a genetic disease. Three or four men in the woman's family, including her father, had a condition that might be genetic. Although her father is still alive, she has had little contact with him for much of her life and cannot describe or name the condition. Her partner is a healthy man whose family has no history indicating the presence of a genetic condition. To provide more information about this possible genetic condition for the couple, what is the first step you recommend?
Problem A.2a
Go online to the Online Mendelian Inheritance of Man (OMIM) website. Look up the following genetic conditions and answer the questions posed about them.
Look up Tay–Sachs disease (TSD), OMIM number 272800, and give the name and abbreviation of the affected gene and the chromosome location of the gene.
Problem A.2b
Go online to the Online Mendelian Inheritance of Man (OMIM) website. Look up the following genetic conditions and answer the questions posed about them.
Go to the 'Population Genetics' section discussing the TSD gene. In a few sentences, summarize the human population in which TSD is most frequently found and give the approximate frequency of heterozygous carriers for the TSD mutation in North American Jews.
Problem A.2c
Go online to the Online Mendelian Inheritance of Man (OMIM) website. Look up the following genetic conditions and answer the questions posed about them.
Look up cystic fibrosis (CF), OMIM 602421, and give the gene name and abbreviation and the chromosome location of the gene.
Problem A.2d
Go online to the Online Mendelian Inheritance of Man (OMIM) website. Look up the following genetic conditions and answer the questions posed about them.
Go to the 'Molecular Genetics' section and describe the most common mutation of the CF gene.
Problem 1a
For bacteria that are F⁺, Hfr, F', and F⁻ perform or answer the following.
Describe the state of the F factor.
Problem 1b
For bacteria that are F⁺, Hfr, F', and F⁻ perform or answer the following.
Which of these cells are donors? Which is the recipient?
Problem 1c
For bacteria that are F⁺, Hfr, F', and F⁻ perform or answer the following.
Which of these donors can convert exconjugants to a donor state?