The most common reason a physician might recommend that a woman have maternal serum screening and a karyotype analysis is concern that her fetus may have Down syndrome. Go to the OMIM website at www.ncbi.nlm.nih.gov/omim and look up Down syndrome (OMIM 190685).

Look at the 'Mapping' and 'Molecular Genetics' sections and describe what is meant by the Down syndrome critical region (DSCR).

The most common reason a physician might recommend that a woman have maternal serum screening and a karyotype analysis is concern that her fetus may have Down syndrome. Go to the OMIM website at www.ncbi.nlm.nih.gov/omim and look up Down syndrome (OMIM 190685).

List the main symptoms of Down syndrome.

The most common reason a physician might recommend that a woman have maternal serum screening and a karyotype analysis is concern that her fetus may have Down syndrome. Go to the OMIM website at www.ncbi.nlm.nih.gov/omim and look up Down syndrome (OMIM 190685).

How might those genes lead to the main symptoms of Down syndrome?

The most common reason a physician might recommend that a woman have maternal serum screening and a karyotype analysis is concern that her fetus may have Down syndrome. Go to the OMIM website at www.ncbi.nlm.nih.gov/omim and look up Down syndrome (OMIM 190685).

Summarize what is known about the location and genes found within the DSCR.

Give descriptions for the following terms:

Histone proteins

Give descriptions for the following terms:

Nucleosome core particle

Give descriptions for the following terms:

Scaffold proteins

Give descriptions for the following terms:

G bands

Give descriptions for the following terms:

Euchromatin

Give descriptions for the following terms:

Heterochromatin