Open QuestionIn this chapter, we focused on how DNA is organized at the chromosomal level. Along the way, we found many opportunities to consider the methods and reasoning by which much of this information was acquired. From the explanations given in the chapter, what answers would you propose to the following fundamental questions:How did we learn that eukaryotic chromatin exists in the form of repeating nucleosomes, each consisting of about 200 base pairs and an octamer of histones?
Open QuestionThe human genome contains 2.9×10⁹ base pairs. Approximately how many nucleosomes are required to organize the 10-nm–fiber structure of the human genome? Show the calculation you use to determine the answer.
Open QuestionIn eukaryotic DNA,how does the role of H1 differ from the role of H3 in chromatin formation?