In some organisms, cytosine is methylated at carbon 5 of the pyrimidine ring after it is incorporated into DNA. If a 5-methyl cytosine molecule is then hydrolyzed, as described in Problem 28, what base will be generated?

What is the chemical basis of molecular hybridization?

What did the Watson–Crick model suggest about the replication of DNA?

A genetics student was asked to draw the chemical structure of an adenine- and thymine-containing dinucleotide derived from DNA. The answer is shown here:The student made more than six major errors. One of them is circled, numbered 1, and explained. Find five others. Circle them, number them 2 through 6, and briefly explain each in the manner of the example given.

One of the most common spontaneous lesions that occurs in DNA under physiological conditions is the hydrolysis of the amino group of cytosine, converting the cytosine to uracil. What would be the effect on DNA structure of a uracil group replacing cytosine?

Consider the drawing of a dinucleotide below. Suppose that the molecule was cleaved with the enzyme spleen phosphodiesterase, which breaks the covalent bond connecting the phosphate to C-5'. After cleavage, to which nucleoside is the phosphate now attached (A or T)?

Consider the drawing of a dinucleotide below. Is the arrow closest to the 5' or the 3' end?

Consider the drawing of a dinucleotide below. Is it DNA or RNA?

A primitive eukaryote was discovered that displayed a unique nucleic acid as its genetic material. Analysis provided the following information:About 75 percent of the sugars are deoxyribose, while 25 percent are ribose. Postulate a model for the structure of this molecule that is consistent with the foregoing observations.