Epistatic gene interaction results in a modification of the F₂ dihybrid ratio.

What is the expected F₂ ratio?

Two pure-breeding strains of summer squash producing yellow fruit, Y₁ and Y₂, are each crossed to a pure-breeding strain of summer squash producing green fruit, G₁, and to one another. The following results are obtained:

If the F₁ of Crosses I and II are mated, predict the phenotype ratio of the progeny. 

Human ABO blood type is determined by three alleles, two of which (I^A and I^B) produce gene products that modify the H antigen produced by protein activity of an independently assorting H gene. A rare abnormality known as the 'Bombay phenotype' is the result of epistatic interaction between the gene for the ABO blood group and the H gene. Individuals with the Bombay phenotype appear to have blood type O based on the inability of both anti-A antibody and anti-B antibody to detect an antigen. The apparent blood type O in Bombay phenotype is due to the absence of H antigen as a result of homozygous recessive mutations of the H gene. Individuals with the Bombay phenotype have the hh genotype. Use the information above to make predictions about the outcome of the cross shown below.

IᴬIᴮHh×IᴬIᴮHh

Epistatic gene interaction results in a modification of the F₂ dihybrid ratio.

Give two examples of modified F₂ ratios produced by epistatic gene interactions and describe how gene interaction results in the ratios.

Epistatic gene interaction results in a modification of the F₂ dihybrid ratio.

What genetic principle is the basis of this expected F₂ ratio?

When performing a complementation test, how do you know if two mutations complement?

How can you tell if two genes are epistatic?

Two heterozygous organisms are crossed, and the F₂ phenotypic ratio is 12:3:1. What form of epistasis do these two genes exhibit?

A cross of white plants and red plants was performed. Using the F2 phenotypic ratio data below, determine what form of gene interaction is taking place.