Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
20. Quantitative Genetics
Heritability
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In this chapter, we focused on a mode of inheritance referred to as quantitative genetics, as well as many of the statistical parameters utilized to study quantitative traits. Along the way, we found opportunities to consider the methods and reasoning by which geneticists acquired much of their understanding of quantitative genetics. From the explanations given in the chapter, what answers would you propose to the following fundamental questions:
How do we know that monozygotic twins are not identical genotypically as adults?

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Congenital dislocation of the hip is a threshold condition in which the head of the femur (the femoral head) is out of its normal position relative to the bones that will form the socket of the hip (the acetabulum). This misplacement can lead to potentially serious orthopedic problems later in life if the condition is not treated in infancy. Numerous studies have shown that (a) brothers and sisters of infants born with congenital hip dislocation are more likely to develop the condition than are the siblings of those without the condition. These studies also find that (b) more female infants than male infants have the trait, and (c) if the affected child is a girl, the risk to her siblings is lower than if the affected infant is a boy. Explain the meaning of the three observations (a, b, and c) in the context of proposing a threshold model that explains these observations.