What is the likely effect of each of the following mutations of the trpL region on attenuation control of trp operon gene transcription? Explain your reasoning. The start (AUG) codon of the trpL polypeptide is deleted.
Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
12. Gene Regulation in Prokaryotes
Tryptophan Operon and Attenuation
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Join thousands of students who trust us to help them ace their exams!Watch the first videoMultiple Choice
Attenuation uses what molecule to regulate the trp operon?
A
All tRNAs
B
Tryptophan
C
Lactose
D
tRNAtrp

1
Understand the concept of attenuation: Attenuation is a regulatory mechanism used by bacteria to control gene expression, particularly in operons involved in amino acid biosynthesis, such as the trp operon.
Identify the role of the trp operon: The trp operon is responsible for the synthesis of tryptophan in bacteria. It is regulated by the availability of tryptophan in the environment.
Recognize the role of tRNA in attenuation: In the context of the trp operon, attenuation involves the use of tRNA molecules, specifically tRNA^trp, which are charged with tryptophan.
Explain the mechanism: When tryptophan levels are high, tRNA^trp is abundant and charged, allowing the ribosome to quickly translate the leader peptide, leading to the formation of a terminator structure in the mRNA that halts transcription.
Conclude the regulation process: When tryptophan levels are low, there is a shortage of charged tRNA^trp, causing the ribosome to stall, which allows the formation of an anti-terminator structure, permitting transcription of the trp operon genes.
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