Multiple Choice
Chromatin remodeling factors move nucleosomes by altering the methylation or acetylation pattern.
7. Gene Expression
Epigenetic Regulation of Gene Expression
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Which of the following modifications is found most often with open chromatin?
A
Acetylation
B
Methylation
C
Phosphorylation
D
Ubiquitination
Verified step by step guidance1
Understand the concept of chromatin structure: Chromatin can exist in two forms, euchromatin (open) and heterochromatin (closed). Open chromatin is associated with active transcription and is more accessible to transcription factors.
Learn about histone modifications: Histones are proteins around which DNA is wrapped, and their chemical modifications can influence chromatin structure and gene expression.
Explore acetylation: Acetylation involves the addition of an acetyl group to histone proteins, which neutralizes the positive charge on histones, reducing their affinity for negatively charged DNA. This process is associated with open chromatin and active transcription.
Compare with other modifications: Methylation can either activate or repress transcription depending on the context, phosphorylation is involved in various cellular processes including chromatin remodeling, and ubiquitination often tags proteins for degradation but can also affect chromatin structure.
Conclude that acetylation is most commonly associated with open chromatin, as it facilitates a relaxed chromatin structure that is accessible for transcription machinery.
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