Multiple Choice
Homologous recombination occurs directly after DNA replication?
16. Cell Division
DNA Repair and Recombination
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Which type of DNA repair is responsible for fixing bulky lesions through a 'cut and paste' method?
A
Base excision repair
B
Mismatch Repair
C
Nucleotide Excision Repair
D
Homologous Recombination
Verified step by step guidance1
Identify the types of DNA damage that each repair mechanism addresses. Bulky lesions are typically caused by UV light or chemical adducts that distort the DNA helix.
Understand that Base Excision Repair (BER) is primarily responsible for fixing small, non-helix-distorting base lesions, such as those caused by oxidation or deamination.
Recognize that Mismatch Repair (MMR) corrects errors that escape proofreading during DNA replication, such as base mismatches and small insertion-deletion loops.
Learn that Homologous Recombination (HR) is a repair mechanism for double-strand breaks, using a homologous sequence as a template for repair, not typically involved in fixing bulky lesions.
Conclude that Nucleotide Excision Repair (NER) is the mechanism that removes bulky DNA lesions by excising a short single-stranded DNA segment containing the lesion and filling in the gap using the undamaged strand as a template, thus employing a 'cut and paste' method.
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