Multiple Choice
Which type of DNA repair is responsible for fixing bulky lesions through a 'cut and paste' method?
16. Cell Division
DNA Repair and Recombination
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Which of the following types of DNA damage occurs when a base is chemically converted into another base?
A
Depurination
B
Deaminatino
C
Thymine Dimer
Verified step by step guidance1
Understand the types of DNA damage: Depurination involves the loss of a purine base (adenine or guanine) from the DNA, resulting in an abasic site. Thymine dimer formation is caused by UV radiation leading to covalent bonding between two adjacent thymine bases.
Focus on the concept of deamination: Deamination is a chemical reaction where an amino group is removed from a molecule. In the context of DNA, this typically involves the conversion of cytosine to uracil, or adenine to hypoxanthine, through the removal of an amino group.
Identify the key feature of the problem: The problem asks for a type of DNA damage where a base is chemically converted into another base. This is a hallmark of deamination, where one base is transformed into another due to the loss of an amino group.
Compare the options: Depurination and thymine dimer formation do not involve the conversion of one base into another. Depurination results in a missing base, while thymine dimers involve the bonding of two existing bases.
Conclude that deamination is the correct type of DNA damage for this scenario, as it specifically involves the chemical conversion of one base into another base.
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