Multiple Choice
Which of the following molecules removes phosphates from PI-3 kinase?
14. Cell Signaling
Phosphoinositide Signaling Pathways
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The inositol signaling pathway can be activated by both GPCRs and RTKs.
A
True
B
False
Verified step by step guidance1
Understand the role of GPCRs (G-protein coupled receptors) and RTKs (receptor tyrosine kinases) in cell signaling. Both are types of receptors that can initiate signaling pathways when activated by ligands.
Learn about the inositol signaling pathway, which involves the production of inositol phosphates, such as IP3, that act as secondary messengers in the cell.
Explore how GPCRs activate the inositol signaling pathway. When a ligand binds to a GPCR, it activates a G-protein, which then stimulates phospholipase C (PLC) to produce IP3 from PIP2.
Investigate how RTKs can also activate the inositol signaling pathway. Upon ligand binding, RTKs undergo autophosphorylation, which can recruit and activate PLCγ, leading to the production of IP3.
Conclude that both GPCRs and RTKs can activate the inositol signaling pathway, as they both have mechanisms to stimulate the production of IP3, a key component of this pathway.
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