Multiple Choice
What is the name of the enzyme that cleaves the miRNA in the nucleus before it travels to the cytoplasm to exert its effects?
7. Gene Expression
Post-Transcriptional Regulators
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When the siRNA interacts with RISC for the first time it is single stranded.
A
True
B
False
Verified step by step guidance1
Understand the role of siRNA (small interfering RNA) in the RNA interference pathway. siRNA is a double-stranded RNA molecule that plays a crucial role in gene silencing.
Learn about the RISC (RNA-induced silencing complex), which is a multiprotein complex that mediates the gene silencing process by using siRNA as a guide to target specific mRNA molecules for degradation.
Recognize that the initial interaction between siRNA and RISC involves the incorporation of double-stranded siRNA into the RISC complex.
Identify the process within the RISC complex where one strand of the siRNA, known as the passenger strand, is cleaved and removed, leaving the guide strand to remain bound to RISC.
Conclude that the siRNA is initially double-stranded when it interacts with RISC, and it becomes single-stranded only after the passenger strand is removed, which is why the statement is false.
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