Skip to main content
Pearson+ LogoPearson+ Logo
Ch. 16 - How Genes Work
Freeman - Biological Science 8th Edition
Freeman8th EditionBiological ScienceISBN: 9780138276263Not the one you use?Change textbook
Chapter 16, Problem 13

A small portion of the human transport protein amino acid sequence is shown here. The upper sequence is associated with darker skin, and the lower sequence is associated with lighter skin. What DNA base-pair change created the light-skin form of the human protein from the gene that coded for the dark-skin form?

Verified step by step guidance
1
Compare the amino acid sequences of the two proteins. Identify the position where the sequences differ.
Note that the third amino acid in the upper sequence is Ala (Alanine) and in the lower sequence is Thr (Threonine).
Determine the codons for Alanine (Ala) and Threonine (Thr). Alanine is coded by GCU, GCC, GCA, or GCG. Threonine is coded by ACU, ACC, ACA, or ACG.
Identify the specific codon change that could result in the amino acid change from Alanine to Threonine. For example, GCU (Alanine) could change to ACU (Threonine).
Conclude that the DNA base-pair change responsible for the amino acid change is a mutation in the codon from GCU to ACU.

Verified video answer for a similar problem:

This video solution was recommended by our tutors as helpful for the problem above.
Video duration:
1m
Was this helpful?

Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

DNA Base-Pair Changes

DNA base-pair changes refer to alterations in the nucleotide sequence of a gene, which can lead to changes in the amino acid sequence of the corresponding protein. These changes can be classified as substitutions, insertions, or deletions, and they can significantly impact protein function and phenotype, such as skin color in humans.
Recommended video:
Guided course
02:30
Introduction to DNA-Based Technology

Amino Acid Sequence

The amino acid sequence of a protein is determined by the order of nucleotides in the corresponding gene. Each set of three nucleotides, known as a codon, codes for a specific amino acid. In the provided sequences, the difference in skin color is linked to a specific change in the amino acid sequence, highlighting the relationship between genetics and phenotypic traits.
Recommended video:

Protein Function and Phenotype

Proteins play crucial roles in determining the physical characteristics of an organism, known as its phenotype. Variations in protein structure, often resulting from genetic mutations, can lead to differences in traits such as skin color. Understanding how specific amino acid changes affect protein function is essential for linking genetic variations to observable traits.
Recommended video:
Guided course
03:54
Membrane Protein Functions
Related Practice
Textbook Question

One of the possibilities considered about the genetic code was that the code was overlapping, meaning that a single base could be part of up to three codons. How many amino acids would be encoded in the sequence 5′-AUGUUACGGAAU-3′ by a non-overlapping and a maximally overlapping triplet code?

a. 4 (non-overlapping) and 16 (overlapping)

b. 4 and 12

c. 4 and 10

d. 12 and 4

Textbook Question

Skin color is often one of the first traits people notice in each other. Studies in zebrafish uncovered a mutation that altered a transport protein and resulted in light-colored fish. This discovery led to the finding that the same gene in humans has a strong influence on skin pigmentation in many populations. The zebrafish mutation that reduced coloration created a null allele of the transport protein gene. Which of the following types of mutation would be most likely to create this null allele?

a. A missense mutation

b. A frameshift mutation

c. A neutral mutation

d. A silent mutation

Textbook Question

Investigators examined the expression of transporter mRNA and protein produced in zebrafish homozygous for each of the alleles and obtained the results summarized here (+=present,−=absent). Does the allele associated with light color appear to be altering transcription ortranslation? Why?

Textbook Question

Researchers compared the amino acid sequences of the transport protein in zebrafish, puffer fish, mice, and humans. They found many stretches with identical sequences in all four species. Does this mean that the corresponding mRNA base sequences are also the same in these four species? Explain why or why not.

Textbook Question

The allele of the human transport protein associated with lighter skin is found almost exclusively in people with European ancestry. The other common allele for darker skin, which appears to be the ancestral allele, is found in people with African ancestry. What is a plausible explanation for how the lighter-skin allele came to be so common in those with European ancestry?