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Problem 1
What results from the experiments of Frederick Griffith provided the strongest support for his conclusion that a transformation factor is responsible for heredity?
Problem 2
Explain why Avery, MacLeod, and McCarty's in vitro transformation experiment showed that DNA, but not RNA or protein, is the hereditary molecule.
Problem 3
Hershey and Chase selected the bacteriophage T2 for their experiment assessing the role of DNA in heredity because T2 contains protein and DNA, but not RNA. Explain why T2 was a good choice for this experiment.
Problem 4
Explain how the Hershey and Chase experiment identified DNA as the hereditary molecule.
Problem 5a
One strand of a fragment of duplex DNA has the sequence 5'-ATCGACCTGATC-3'.
What is the sequence of the other strand in the duplex?
Problem 5b
One strand of a fragment of duplex DNA has the sequence 5'-ATCGACCTGATC-3'.
What is the name of the bond that joins one nucleotide to another in the DNA strand?
Problem 5c
One strand of a fragment of duplex DNA has the sequence 5'-ATCGACCTGATC-3'.
Is the bond in part (b) a covalent or a noncovalent bond?
Problem 5d
One strand of a fragment of duplex DNA has the sequence 5'-ATCGACCTGATC-3'.
Which chemical groups of nucleotides react to form the bond in part (b)?
Problem 5e
One strand of a fragment of duplex DNA has the sequence 5'-ATCGACCTGATC-3'.
What enzymes catalyze the reaction in part (d)?
Problem 5f
One strand of a fragment of duplex DNA has the sequence 5'-ATCGACCTGATC-3'.
Identify the bond that joins one strand of a DNA duplex to the other strand.
Problem 5g
One strand of a fragment of duplex DNA has the sequence 5'-ATCGACCTGATC-3'.
Is the bond in part (f) a covalent or a noncovalent bond?