Researchers have identified some tumors that have no recurrent mutations or deletions in known oncogenes or tumor-suppressor genes and no detectable epigenetic alterations. However, these tumors often have large chromosomal deletions. What are some possible explanations that could account for the genetic causes behind these tumors?
Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
19. Cancer Genetics
Cancer Mutations
Struggling with Genetics?
Join thousands of students who trust us to help them ace their exams!Watch the first videoMultiple Choice
Which of the following proteins is an example of a tumor suppressor?
A
Ras GTPase
B
HPV E6 protein
C
p53 transcription factor

1
Understand the role of tumor suppressor proteins: Tumor suppressor proteins are crucial in regulating cell division, repairing DNA mistakes, and ensuring cells do not proliferate uncontrollably.
Identify the function of p53: The p53 transcription factor is a well-known tumor suppressor that plays a key role in preventing cancer formation by inducing cell cycle arrest, apoptosis, or senescence in response to DNA damage.
Differentiate between oncogenes and tumor suppressors: Oncogenes, like Ras GTPase, promote cell division and survival, whereas tumor suppressors, like p53, inhibit these processes to prevent tumor development.
Examine the role of HPV E6 protein: HPV E6 protein is not a tumor suppressor; it is an oncogenic protein that can degrade p53, thereby promoting cancer progression.
Conclude with the identification: Based on the functions and roles, p53 is the correct example of a tumor suppressor protein among the options provided.
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