Table of contents

1. Introduction to Genetics51m
2. Mendel's Laws of Inheritance3h 37m
3. Extensions to Mendelian Inheritance2h 41m
4. Genetic Mapping and Linkage2h 28m
5. Genetics of Bacteria and Viruses1h 21m
6. Chromosomal Variation1h 48m
7. DNA and Chromosome Structure56m
8. DNA Replication1h 10m
9. Mitosis and Meiosis1h 34m
10. Transcription1h 0m
11. Translation58m
12. Gene Regulation in Prokaryotes1h 19m
13. Gene Regulation in Eukaryotes44m
14. Genetic Control of Development44m
15. Genomes and Genomics1h 50m
16. Transposable Elements47m
17. Mutation, Repair, and Recombination1h 6m
18. Molecular Genetic Tools19m
- Genetic Cloning
  9m
- Methods for Analyzing DNA
  9m
19. Cancer Genetics29m
- Overview of Cancer
  21m
- Cancer Mutations
  7m
20. Quantitative Genetics1h 26m
21. Population Genetics50m
- Hardy Weinberg
  19m
- Allelic Frequency Changes
  31m
22. Evolutionary Genetics29m

17. Mutation, Repair, and Recombination

DNA Repair

Genetics

17. Mutation, Repair, and Recombination

DNA Repair

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Answer the following questions concerning the accuracy of DNA polymerase during replication.

If the kind of abnormality identified in part (c) is not corrected before the next DNA replication cycle, what kind of mutation occurs?

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Open Question

Write a short essay contrasting how these concepts may differ between bacteria and eukaryotes.

Open Question

Answer the following questions concerning the accuracy of DNA polymerase during replication.

Identify two mechanisms that can correct the kind of abnormality resulting from the circumstances identified in part (c).

Open Question

Answer the following questions concerning the accuracy of DNA polymerase during replication.

If a DNA replication error is detected by DNA polymerase, how is it corrected?

Open Question

Answer the following questions concerning the accuracy of DNA polymerase during replication.

DNA mismatch repair can accurately distinguish between the template strand and the newly replicated strand of a DNA duplex. What characteristic of DNA strands is used to make this distinction?

Open Question

Answer the following questions concerning the accuracy of DNA polymerase during replication.

If a replication error escapes detection and correction, what kind of abnormality is most likely to exist at the site of replication error?

Open Question

Answer the following questions concerning the accuracy of DNA polymerase during replication.

What general mechanism do DNA polymerases use to check the accuracy of DNA replication and identify errors during replication?

Open Question

DNA damage brought on by a variety of natural and artificial agents elicits a wide variety of cellular responses involving numerous signaling pathways. In addition to the activation of DNA repair mechanisms, there can be activation of pathways leading to apoptosis (programmed cell death) and cell-cycle arrest. Why would apoptosis and cell-cycle arrest often be part of a cellular response to DNA damage?

Open Question

Contrast the various types of DNA repair mechanisms known to counteract the effects of UV radiation. What is the role of visible light in repairing UV-induced mutations?

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