Sickle cell disease (SCD) is found in numerous populations whose ancestral homes are in the malaria belt of Africa and Asia. SCD is an autosomal recessive disorder that results from homozygosity for a mutant β-globin gene allele. Data on one affected population indicates that approximately 8 in 100 newborn infants have SCD.What is the frequency of carriers of SCD in the population?

Genetic Analysis 20.1 predicts the number of individuals expected to have the blood group genotypes MM, MN, and NN. Perform a chi-square analysis using the number of people observed and expected in each blood-type category, and state whether the sample is in H-W equilibrium (see Section 2.5 for the chi-square formula and table).

In a population of rabbits, f(C₁) = 0.70 and f(C₂) = 0.30. The alleles exhibit an incomplete dominance relationship in which C₁C₁ produces black rabbits, C₁C₂ produces tan-colored rabbits, and C₂C₂ produces rabbits with white fur. If the assumptions of the Hardy–Weinberg principle apply to the rabbit population, what are the expected frequencies of black, tan, and white rabbits?

Sickle cell disease (SCD) is found in numerous populations whose ancestral homes are in the malaria belt of Africa and Asia. SCD is an autosomal recessive disorder that results from homozygosity for a mutant β-globin gene allele. Data on one affected population indicates that approximately 8 in 100 newborn infants have SCD.What are the frequencies of the wild-type (βᴬ) and mutant (βˢ) alleles in this population?

Epidemiologic data on the population in the previous problem reveal that before the application of modern medical treatment, natural selection played a major role in shaping the frequencies of alleles. Heterozygous individuals have the highest relative fitness, and in comparison with heterozygotes, those who are βᴬβᴬ have a relative fitness of 82%, but only about 32% of those with SCD survived to reproduce. What are the estimated equilibrium frequencies of βᴬ and βˢ in this population?

The frequency of tasters and nontasters of PTC (see Problem 10) varies among populations. In population A, 64% of people are tasters (an autosomal dominant trait) and 36% are nontasters. In population B, tasters are 75% and nontasters 25%. In population C, tasters are 91% and nontasters are 9%.Calculate the frequency of the dominant (T) allele for PTC tasting and the recessive (t) allele for nontasting in each population.

The frequency of tasters and nontasters of PTC (see Problem 10) varies among populations. In population A, 64% of people are tasters (an autosomal dominant trait) and 36% are nontasters. In population B, tasters are 75% and nontasters 25%. In population C, tasters are 91% and nontasters are 9%.Assuming that Hardy–Weinberg conditions apply, determine the genotype frequencies in each population.

Cystic fibrosis (CF) is the most common autosomal recessive disorder in certain Caucasian populations. In some populations, approximately 1 in 2000 children have CF. Determine the frequency of CF carriers in this population.