A female of genotypea b c + + +produces 100 meiotic tetrads. Of these, 68 show no crossover events. Of the remaining 32, 20 show a crossover between a and b, 10 show a crossover between b and c, and 2 show a double crossover between a and b and between b and c. Of the 400 gametes produced, how many of each of the 8 different genotypes will be produced? Assuming the order a–b–c and the allele arrangement previously shown, what is the map distance between these loci?

A 2006 genetic study of a large American family (Ikeda et al., 2006) identified genetic linkage between DNA markers on chromosome 11 and the gene producing the autosomal dominant neuromuscular disorder spinocerebellar ataxia type 5 (SCA5). The following lod score data are taken from the 2006 study:                                     Theta (θ) Value               0.01    0.05     0.10     0.20     0.30     0.40SCA5    11.02   12.26   11.94   10.04    7.26     3.77 and DNA marker A SCA5    0.35.    0.94.     1.07     0.99     0.75    0.43 and DNA marker B Based on the available information, is DNA marker A linked to the gene producing SCA5? Explain your answer.

A 2006 genetic study of a large American family (Ikeda et al., 2006) identified genetic linkage between DNA markers on chromosome 11 and the gene producing the autosomal dominant neuromuscular disorder spinocerebellar ataxia type 5 (SCA5). The following lod score data are taken from the 2006 study:                                     Theta (θ) Value               0.01    0.05     0.10     0.20     0.30     0.40SCA5    11.02   12.26   11.94   10.04    7.26     3.77 and DNA marker A SCA5    0.35.    0.94.     1.07     0.99     0.75    0.43 and DNA marker B What is the maximum value for each set of lod scores?

A 2006 genetic study of a large American family (Ikeda et al., 2006) identified genetic linkage between DNA markers on chromosome 11 and the gene producing the autosomal dominant neuromuscular disorder spinocerebellar ataxia type 5 (SCA5). The following lod score data are taken from the 2006 study:                                     Theta (θ) Value               0.01    0.05     0.10     0.20     0.30     0.40SCA5    11.02   12.26   11.94   10.04    7.26     3.77 and DNA marker A SCA5    0.35.    0.94.     1.07     0.99     0.75    0.43 and DNA marker B Does either group of lod scores indicate statistically significant odds in favor of genetic linkage? Explain your answer.

A 2006 genetic study of a large American family (Ikeda et al., 2006) identified genetic linkage between DNA markers on chromosome 11 and the gene producing the autosomal dominant neuromuscular disorder spinocerebellar ataxia type 5 (SCA5). The following lod score data are taken from the 2006 study:

                                    Theta (θ) Value
               0.01    0.05     0.10     0.20     0.30     0.40
SCA5    11.02   12.26   11.94   10.04    7.26     3.77
and
DNA
marker A

SCA5    0.35.    0.94.     1.07     0.99     0.75    0.43
and
DNA
marker B

Based on available information, is DNA marker B linked to the gene for SCA5? Explain your answer.

A genetic study of an early onset form of heart disease identifies 10 families containing members with the condition. No clear dominant or recessive pattern of inheritance is evident, but an analysis of SNP markers for five families detects a strong association with a marker on chromosome 12, and genetic linkage analysis for the marker produces a lod score of 2.2.

What next step do you recommend for this genetic analysis?

A genetic study of an early onset form of heart disease identifies 10 families containing members with the condition. No clear dominant or recessive pattern of inheritance is evident, but an analysis of SNP markers for five families detects a strong association with a marker on chromosome 12, and genetic linkage analysis for the marker produces a lod score of 2.2.

What do the association and lod score results suggest about this genetic marker?

DNA sequences for 10 individuals are

                          Nucleotide Position
                       1               5                  10
Person 1            ...GACCTATTGC...
Person 2            ...GAACTATTGC...
Person 3            ...GACCTTTTGC...
Person 4             ...GACCTATTGC...
Person 5             ...CAACTATTGC...
Person 6             ...GACCTTTTGC...
Person 7              ...CAACTATTGC...
Person 8              ...GACCTATTGC...
Person 9              ...CAACTATTGC...
Person 10            ...GAACTATTGC...

Identify the haplotype carried by each person.