Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
6. Chromosomal Variation
Chromosomal Rearrangements: Inversions
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Join thousands of students who trust us to help them ace their exams!Watch the first videoMultiple Choice
A person has a WT chromosome with the following segments. A B C • D E F G H. Which of the following shows how the chromosome would look after a pericentric inversion?
A
A B C • D E F G H
B
A B E D • C F G H
C
A B C • D G H
D
A B C • D G E F H

1
Understand that a pericentric inversion involves a segment of a chromosome that includes the centromere. The segment is inverted, meaning it is flipped in orientation.
Identify the segments involved in the inversion. In this case, the segments between 'C' and 'D' are inverted, which includes the centromere (•).
Determine the new order of the segments after inversion. The segments 'C', 'D', 'E', and 'F' are involved in the inversion.
Flip the order of the segments involved in the inversion. The original order 'C • D E F' becomes 'E D • C F' after inversion.
Reconstruct the chromosome with the inverted segment. The chromosome now reads 'A B E D • C F G H'.
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Open Question
A couple planning their family are aware that through the past three generations on the husband's side a substantial number of stillbirths have occurred and several malformed babies were born who died early in childhood. The wife has studied genetics and urges her husband to visit a genetic counseling clinic, where a complete karyotype-banding analysis is performed. Although the tests show that he has a normal complement of 46 chromosomes, banding analysis reveals that one member of the chromosome 1 pair (in group A) contains an inversion covering 70 percent of its length. The homolog of chromosome 1 and all other chromosomes show the normal banding sequence.What can you predict about the probability of abnormality/normality of their future children?
Chromosomal Rearrangements: Inversions practice set
