Open Question
Thinking back to the discussion of gain-of-function and loss-of-function mutations in Section 4.1, and putting those concepts together with the discussion of base substitution mutations in this chapter, explain why gain-of-function mutations are often dominant and why loss-of-function mutations are often recessive. Give an example of a type of gain-of-function mutation that is dominant and of a loss-of-function mutation that is recessive.
