A powerful approach to identifying genes of a developmental pathw...

Question

A powerful approach to identifying genes of a developmental pathway is to screen for mutations that suppress or enhance the phenotype of interest. This approach was undertaken to elucidate the genetic pathway controlling C. elegans vulval development.A lin-3 loss-of-function mutant with a vulva-less phenotype was mutagenized. Based on your knowledge of the genetic pathway, what types of mutations will suppress the vulva-less phenotype?

Accepted Answer

Hey, everyone. Let's take a look at this question together which type of mutation is seen in the C F T R gene or the cystic fibrosis transmembrane conductance regulator gene that results in the production of a nonfunctional or less functional protein leading to thick sticky mucus build-up in the lungs and digestive tract. Is it answer choice. A nonsense mutation. Answer choice B missense mutation, answer choice, C loss of function mutation or answer choice D gain of function mutation. Let's work this problem out together to try to figure out which type of mutation is seen in the C F T R gene resulting in a nonfunctional or less functional protein. Since we are talking about C F T R, which is that cystic fibrosis transmembrane conductance regulator, we know that C F T R regulates the movement of salt and water in and out of the cells. And in this case, we have a mutation that results in the production of a nonfunctional or less functional protein in the C F T R gene. So we have a non functional or a less functional protein and we know that this is caused Y A change in the amino acid sequence because of that nonfunctional or less functional protein. And as a result of that nonfunctional and less functional protein, it leads to m proper holding. And so this change in the amino acid sequence is due to a point mutation, more specifically a point mutation that changes the amino acid in the sequence or another amino acid, which is a type of point mutation that is called a miss sense mutation. Since a missense mutation is a type of point mutation that alters that amino acid in the amino acid sequence and replaces it with another amino acid that is not the original one. And so answer choice. B missense mutation is the correct answer because we have a nonfunctional or less functional protein that is caused by that change in the amino acid sequence, which is a result of a point mutation that changes the amino acid in the amino acid sequence of that C F T R gene or another amino acid giving us that missense mutation which leads to the thick sticky mucus build-up in the lungs and digestive tract. Since the C F T R gene is not operating normally because of that missense mutation. I hope you found this video to be helpful. Thank you and goodbye.

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