Multiple Choice
Apoptosis can only be stimulated through intracellular signals.
16. Cell Division
Control of Cell Death
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In the intrinsic pathway of regulating apoptosis, Bcl2 controls what?
A
It releases cytochrome C from the mitochondria
B
It binds to cytochrome C and prevents its release
C
It binds to Bad and Bax and prevents cytochrome C release
D
It binds to Bad and Bax and triggers cytochrome C release
Verified step by step guidance1
Understand the role of Bcl2 in the intrinsic pathway of apoptosis. Bcl2 is a member of the Bcl-2 family of proteins, which are key regulators of apoptosis.
Recognize that the intrinsic pathway of apoptosis is primarily regulated by the mitochondria and involves the release of cytochrome C into the cytosol.
Identify that Bcl2 functions as an anti-apoptotic protein. It prevents apoptosis by inhibiting the release of cytochrome C from the mitochondria.
Learn that Bcl2 achieves this by binding to pro-apoptotic proteins such as Bad and Bax. These proteins promote the release of cytochrome C when not inhibited.
Conclude that Bcl2's binding to Bad and Bax prevents the release of cytochrome C, thereby inhibiting the apoptotic process.
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