Multiple Choice
cAMP levels are kept at high levels in the cell.
14. Cell Signaling
G Protein Coupled Receptors
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Which of the following is true regarding G-protein coupled receptors?
A
It contains three transmembrane sections
B
The G protein binds the intracellular side of the G protein coupled receptors
C
There are four intracellular and extracellular loops
D
G proteins respond only to calcium
Verified step by step guidance1
Understand the structure of G-protein coupled receptors (GPCRs): GPCRs typically have seven transmembrane alpha-helices, not three. This is a key structural feature that distinguishes them from other types of receptors.
Recognize the role of G-proteins: G-proteins are intracellular proteins that bind to the intracellular side of GPCRs. This binding is crucial for the transmission of signals from the outside to the inside of the cell.
Identify the loops in GPCRs: GPCRs have three extracellular loops and three intracellular loops, not four of each. These loops play a role in ligand binding and signal transduction.
Clarify the response of G-proteins: G-proteins do not respond only to calcium. They are involved in a variety of signaling pathways and can be activated by different ligands binding to the GPCR.
Evaluate the statements: Based on the above clarifications, determine which statement accurately describes a characteristic of GPCRs, focusing on the interaction between the G-protein and the receptor.
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