Multiple Choice
MHC class I is used to activate which of the following cell types?
21. The Immune System
MHC and Antigen Presentation
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Which MHC class presents intracellular pathogens?
A
MHC class I
B
MHC class II
Verified step by step guidance1
Understand the role of Major Histocompatibility Complex (MHC) molecules in the immune system. MHC molecules are responsible for presenting antigens to T cells, which is crucial for the immune response.
Differentiate between MHC class I and MHC class II molecules. MHC class I molecules are found on all nucleated cells, whereas MHC class II molecules are primarily on antigen-presenting cells like macrophages, dendritic cells, and B cells.
Recognize the types of antigens presented by each MHC class. MHC class I molecules present endogenous antigens, which are typically derived from intracellular pathogens such as viruses.
Understand the process of antigen presentation by MHC class I. Intracellular proteins are degraded into peptides by the proteasome, transported into the endoplasmic reticulum, and loaded onto MHC class I molecules.
Learn about the interaction between MHC class I molecules and CD8+ T cells. Once the MHC class I molecule presents the peptide on the cell surface, it is recognized by CD8+ cytotoxic T cells, which can then initiate an immune response against the infected cell.
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