Multiple Choice
Which of the following is not true regarding gluconeogenesis?
10. Anerobic Respiration
Gluconeogenesis
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When phosphofructokinase-1 is active, what happens to gluconeogenesis?
A
It is also activated
B
It is repressed
C
Nothing
Verified step by step guidance1
Understand the role of phosphofructokinase-1 (PFK-1) in cellular metabolism. PFK-1 is a key regulatory enzyme in glycolysis, catalyzing the conversion of fructose-6-phosphate to fructose-1,6-bisphosphate.
Recognize that glycolysis and gluconeogenesis are opposing pathways. Glycolysis breaks down glucose to produce energy, while gluconeogenesis synthesizes glucose from non-carbohydrate precursors.
Identify the regulatory mechanisms that coordinate glycolysis and gluconeogenesis. When glycolysis is active, gluconeogenesis is typically repressed to prevent a futile cycle where glucose is simultaneously broken down and synthesized.
Consider the effect of PFK-1 activation on glycolysis. When PFK-1 is active, it enhances the glycolytic pathway, increasing the breakdown of glucose.
Conclude that when PFK-1 is active and glycolysis is upregulated, gluconeogenesis is repressed to conserve energy and resources, as the cell prioritizes energy production over glucose synthesis.
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