Multiple Choice
What is the name of the signal released by some proteins when they can be degraded?
6. Proteins
Protein Degradation
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Before entering the proteasome the protein marked for degradation is unfolded.
A
True
B
False
Verified step by step guidance1
Understand the role of the proteasome: The proteasome is a protein complex responsible for degrading unwanted or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds.
Recognize the process of protein degradation: Proteins targeted for degradation are tagged with a small protein called ubiquitin. This process is known as ubiquitination.
Identify the importance of unfolding: Before a protein can be degraded by the proteasome, it must be unfolded. This is because the proteasome's catalytic core can only accommodate linear polypeptide chains.
Consider the mechanism of unfolding: The proteasome has regulatory particles that recognize ubiquitinated proteins and use ATP to unfold them, allowing the linear polypeptide to enter the proteasome's core.
Conclude the process: Once unfolded, the protein is translocated into the proteasome where it is cleaved into smaller peptides, completing the degradation process.
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