Hydrolysis of Nucleosides quiz Flashcards
Hydrolysis of Nucleosides quiz
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Which component of an RNA nucleotide makes it more prone to hydrolysis than DNA?
The presence of a hydroxyl group on the 2' carbon of ribose in RNA makes it more prone to hydrolysis than DNA. What are the products of nucleoside hydrolysis?
The hydrolysis of a nucleoside produces a free sugar and a nitrogenous base. What is the first step in the acid-catalyzed hydrolysis mechanism of nucleosides?
The first step is a proton transfer. What occurs during the second step of nucleoside hydrolysis?
The second step involves the loss of the leaving group. What happens in the third step of the nucleoside hydrolysis mechanism?
The third step is a nucleophilic attack. What is the final step in the acid-catalyzed hydrolysis of nucleosides?
The final step is another proton transfer. Why are nucleosides not easily hydrolyzed?
Nucleosides are not easily hydrolyzed because they require a strong acid and sufficient time for the reaction to occur. What role does a strong acid play in nucleoside hydrolysis?
A strong acid catalyzes the hydrolysis of nucleosides by facilitating proton transfers and the loss of the leaving group. What is the significance of understanding the steps in nucleoside hydrolysis?
Understanding the steps is crucial for grasping the overall mechanism of nucleoside acidic hydrolysis. What is the main difference between RNA and DNA that affects their stability?
RNA has a hydroxyl group on the 2' carbon of ribose, making it less stable and more prone to hydrolysis compared to DNA.
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